The development of Six Nations (originally called Grand River) Polytechnical Institute began in 1993 with the first program offered - a Preparation for Employment program which was funded through a Jobs Ontario project administered by Grand River Employment and Training.

The University Consortium was formed the year after (1994) with the first University Articulation Agreement developed with five universities: McMaster University, Brock University, the University of Guelph, the University of Waterloo and Wilfrid Laurier University.   This agreement allowed students to complete the first year of university in the community of Six Nations-Native University Access Program.

Six Nations Polytechnic began to develop partnerships with many universities and colleges to offer post-secondary education programs to the community of Six Nations and the surrounding communities. Universities include; McMaster University, Brock University,  University of Waterloo, University of Guelph, University of Western Ontario, Wilfrid Laurier and Ontario College of Art University. Colleges included; Niagara, Mohawk, Fanshawe, George Brown, Conestoga, Sheridan and St. Lawrence.

A focus to develop health-based programming began in 1999, currently, SNP partners with Mohawk College to deliver 3 nursing degree and diploma programs, plus a variety of health care programs and certificates.

The addition of Teaching Qualification courses implemented in 2014 and continues today with the offer of six certificate programs.

The vision and development of a full Language Degree program began in 1994 and was approved by the Ministry in 2016. Today SNP's Ogweho:weh Language BA is a fully accredited Degree program and runs out of both the Six Nations and Brantford campuses. 

SNP has successfully delivered post-secondary education and training programs for the past twenty-three years that have allowed their students to further their education and careers goals in a wide variety of program offerings and career choices.